Southend’s Harry Lennon has been ruled out for a number of months after suffering a knee injury.
The centre-back will need surgery on the problem having struggled with it for weeks and will start by missing out against Forest Green.
Ashley Nathaniel-George, Emile Acquah and Kazaiah Sterling will all be unavailable due to coronavirus restrictions.
The outbreak forced the Shrimpers to postpone Saturday’s clash with Cambridge. Alan McCormack could return after a calf problem but Kyle Taylor is likely to miss out with a hamstring injury.
Forest Green could be without winger Scott Wagstaff.
The wideman has been sidelined for the last four matches after suffering a hamstring injury in their win against Leyton Orient.
Defender Jayden Richardson was left out of Saturday’s 2-2 draw at Barrow after completing a period of self isolation but is available.
Forward Aaron Collins is also pushing for recall after coming off the bench at the weekend.