Sam Winnall will miss Oxford’s League One clash with Peterborough.
The 30-year-old striker’s ankle problem is worse than first feared.
James Henry will face a late fitness test, with the midfielder struggling due to a hamstring issue.
Midfielder Marcus McGuane is out for the rest of the season due to a thigh injury.
Ronnie Edwards will miss out for Peterborough with a muscular injury, but the teenage defender is expected back in action before the end of the season.
Louis Reed and Frazer Blake-Tracy will come into contention for a return to the match squad.
The duo impressed in Friday’s friendly against Ipswich, pushing their selection case.
Peterborough will be looking for a seventh straight league win to stay top of the table.