Preston manager Alex Neil will be without Tom Bayliss for the visit of Charlton.
The midfielder damaged his ankle during a behind-closed-doors game against Accrington and could be out for a number of weeks.
Neil could hand new signing Scott Sinclair a home debut after he came off the bench during last weekend’s draw at Blackburn.
Daniel Johnson is back in training after six weeks out but may have to wait for a first-team comeback, while Andrew Hughes is a doubt. Billy Bodin and Louis Moult are definitely missing through injury and Josh Ginnelly has joined Bristol Rovers on loan.
Charlton have lost the services of on-loan midfielder Conor Gallagher.
The 19-year-old has been recalled by parent club Chelsea, much to the disappointment of manager Lee Bowyer, who told the club website: “I didn’t see this coming if I’m honest which makes it harder to take.”
In a boost for the Addicks, Chuks Aneke is nearing a first-team return, and is expected to feature for the under-23s on Saturday.
Macauley Bonne will remain sidelined for the next few weeks, but Jonny Williams, Tomer Hemed and Jake Forster-Caskey have returned to the fold and could be included in the matchday squad.