On-loan Ipswich midfielder Idris El Mizouni is set to make his full Cambridge debut at home to Salford.
The 19-year-old midfielder made his first appearance as a substitute in Saturday’s draw at Morecambe but now looks likely to be involved from the start.
Sam Smith is set to be absent for some time after being admitted to hospital with illness last week.
Samir Carruthers is unavailable due to “personal reasons”.
George Tanner could make his debut for Salford after signing on loan from Manchester United last week having spent the first half of the season at Morecambe.
Joey Jones missed the weekend draw with Oldham, having only just come back from injury four days previously in the Leasing.com Trophy, and is doubtful.
Tom Elliott is pushing for his first league start following his move from Oxford.
Craig Conway could also be in contention for a return having been rested on Saturday.