Cambridge boss Colin Calderwood plans to include Samir Carruthers in his squad against Plymouth following his return from a hamstring injury.
Calderwood will be without George Taft, with the defender suffering from a calf injury.
Marc Richards will also miss out due to injury and Leon Davies is another unlikely to feature.
Sam Smith could be in the matchday squad but will not be risked if his persistent groin issue flares up before the game.
Callum McFadzean has returned to training and could feature in Ryan Lowe’s Plymouth squad.
He was substituted due to a knee injury as the Pilgrims drew with Bristol Rovers in the second round of the FA Cup on Sunday, but he has since rejoined training.
A late fitness test will determine whether McFadzean is involved.
Defender Will Aimson will not take part as he remains sidelined due to a pelvis injury.