Colchester captain Luke Prosser could miss his side’s Easter fixtures due to an ankle injury.
The U’s are waiting on the results of a scan before determining whether the defender can play any part in the Sky Bet League Two double-header, with the visit of Grimsby up first on Friday.
Midfielder Brandon Comley has returned to training after two months out with a knee injury but the matches come too soon for his first-team return.
Midfielder Louis Dunne, though, comes into contention after coming through 45 minutes of an under-23 game on Monday after so far missing the season with a cruciate ligament injury.
Striker Ahkeem Rose is poised to return for Grimsby after missing the last two matches with a hamstring injury.
While Rose returned to training this week, manager Michael Jolley says he has not done enough to be considered for a start so is likely to be on the bench.
Jolley continues to be without Ludvig Ohman, Jordan Cook, Elliot Embleton and Elliott Whitehouse through injury.
It remains to be seen whether striker Wes Thomas returns after missing the last two matches following an alleged fallout with Jolley.