Oxford will check on the fitness of midfielder Cameron Brannagan ahead of the visit of Ipswich.
Brannagan was forced off at half-time with a knee problem during Saturday’s 3-1 defeat by Rotherham.
Top scorer James Henry is out with a thigh injury which could sideline him for six weeks.
Loanees Marcus Browne and Nathan Holland are pushing for starts after impressing on their debuts off the bench against the Millers.
Ipswich are likely to be unchanged following their 4-1 win over Accrington.
Defender Janoi Donacien is fit after a dead leg and was among the substitutes at the weekend, but midfielder Jon Nolan is still a doubt with a heel problem.
Teddy Bishop made another substitute appearance on his comeback from a long-term knee injury and should be involved again.
Striker Freddie Sears is also building up his fitness following a knee injury.