George Clooney shared a kiss with his wife Amal before receiving a lifetime achievement award.
Jennifer Aniston and Courtney Cox, Bill Murray, Cate Blanchett, Diane Keaton, Jimmy Kimmel, Anna Kendrick, Don Cheadle and even former US president Barack Obama paid tribute to the Hollywood star.
Mr Obama appeared by videotape, while Kimmel touched on Clooney’s love of pranks, quipping that his greatest was ”convincing Roseanne (Barr) to open a Twitter account”, The Hollywood Reporter said.
During the event, Clooney, 57, joked about the first birthday of his twins, Ella and Alexander, US website People said.
“Well, the kids got drunk. I came home they had a bottle of booze. They’re feeling better today,” the actor said, before adding of family life: “It’s perfect.”
The 46th American Film Institute’s Life Achievement Award was held in Los Angeles.