Dons teenagers Lewis Ferguson and Connor McLennan are set to be fit to face Hearts despite recent injury scares.
Both were forced to withdraw from the recent Scotland Under-21 training camp in Marbella.
Winger McLennan, 19, pulled out before Scot Gemmill’s young Scots jetted out to Spain.
Midfielder Ferguson, 19, made the trip but sat out the 0-0 draw with Mexico U22s on Friday.
Due to a thigh strain Ferguson hardly trained with the squad during his time in Marbella.
He flew home early before Scotland suffered a 2-1 friendly defeat to Sweden on Monday.
Aberdeen boss Derek McInnes is confident both will recover in time for the trip to Tynecastle.
In a further fitness boost, McInnes also confirmed Andy Considine, who missed the 1-1 draw with Livingston, is expected to be fit to face the Jambos.
McInnes said: “Lewis had to pull out of the U21 squad due to a little thigh strain. We have asked a lot of Lewis this season and he has responded.
“It is maybe just the effects of too much football with the level he has been playing at.
“Connor is another one who we are trying to manage.
“Lewis should be okay for the weekend thankfully and we are hoping Connor, Greg (Stewart) and Andy (Considine) will all be back and fully functioning for the game at Tynecastle.”
The Dons went into the two- week international break on the back of a laboured 1-1 draw with Livingston at Pittodrie.
McInnes accepts some of his players were feeling the repercussions of a tough schedule that had included away trips to both Rangers and Celtic within a short period.
He said: “We had more than a few that were feeling the effects of the schedule and we had been asking a lot of the same boys to keep playing week in, week out.
“We had a few boys working and performing with a few knocks and the rest will have done them good.
“Andy (Considine) just missed out on the Livingston game after the effects of the matches against Rangers and Celtic.
“The break came at a good time for us and allowed us to dust ourselves down.
“With eight games to go there is plenty to play for in the Premiership when we return.”
Another player McInnes hopes benefits from the international break is Greg Stewart.
The on-loan Birmingham City attacker has been struggling with a hip complaint.
McInnes gave the 29-year-old 10 days off from training during the international shutdown to allow Stewart to fully recuperate from the problem.
He said: “We have really been trying to manage Greg for a while now as he has a hip complaint.
“That was gradually becoming more of an issue and his training week has not been as we would have liked. Greg actually picked up the injury against Kilmarnock, in one of his first games for us and it has gradually become more of an issue.
“His training weeks have not been what we would have liked and unfortunately Greg has lost a bit of momentum from that.
“We needed to get him fit as he needed rest for 10 days or so to get him fully functioning.
“The rest and the work with the physios had done Greg good and he will be back more into the swing of things before Hearts.
“So we got him shut down for 10 days or so and hopefully he will come back full pelt.”
Meanwhile, Aberdeen have sold in excess of 10,000 tickets of their initial allocation of 14,500 for the Scottish Cup semi-final against Celtic.
The Dons face the cup holders at Hampden on Sunday April 14.
An additional 3,000 briefs will be made available to the Dons, if strong demand is demonstrated, which it is understood is an option the club will take.