A city university is trialling a new drug to treat breast cancer and diabetes by melting away fat inside arteries.
Researchers from the University of Aberdeen have found that a single dose of drug Trodusquemine can reverse the effects that can cause a host of heart problems.
Atherosclerosis is the build-up of fatty material inside arteries which can cause heart attacks and strokes.
In pre-clinical tests, mice with atherosclerosis had less fatty plaques in their arteries whether they had regular doses over time or just a single dose of Trodusquemine.
The drug stops an enzyme found in people who are obese or diabetic, and has already been effective with diabetes and breast cancer patients – but this is the first time it has been shown to have benefits for long-term cardiovascular disease.
Dr Dawn Thompson and Professor Mirela Delibegovic, from the university’s Institute of Medical Sciences, led the study funded by the British Heart Foundation.
Prof Delibegovic said: “Trodusquemine has been trialled for treatment of diabetes and breast cancer, but this is the first time it’s been used in models of atherosclerosis.”