On-loan Manchester United striker James Wilson is ruled out of tomorrow’s clash at St Johnstone through injury.
The 24-year-old has failed to shake off a tight hamstring in time for the Premiership clash in Perth.
Wilson, who signed a season-long loan from the Premier League giants, has yet to start for the Dons.
The former England U21 international came on as a second half substitute in the 1-1 draw with Hibs at Easter Road.
Meanwhile, Scotland international centre-back Scott McKenna is set to return from a six week absence due to a hamstring tear.
McKenna missed four Dons games due to the injury and was also ruled out of Scotland’s recent double header against Belgium and Albania.
McInnes said: “James Wilson remains out for tomorrow but will hopefully be back for next week.
“If the St Johnstone game was a cup final we could probably throw him in and take a gamble on it.
“But with so many games coming up and it being so early in the season it is important for us that we try to get James a full week of training ahead of any game.
“Especially in the light of him being out, so that is the course of action we have taken.”
“The good news is that Scott McKenna returns tomorrow.
“However, we still have several players out injured including Mark Reynolds, Greg Tansey, Scott Wright, Tommie Hoban and Frank Ross.
“And Mikey Devlin is suspended.”
Dons boss McInnes has also confirmed the loan capture of Derby’s Max Lowe was designed to allow Graeme Shinnie to return to midfield.
A defensive injury crisis forced McInnes to switch club captain Shinnie to the left-back role.
McInnes and Shinnie both believe the 27-year-old’s best position is in the centre of pitch.
The addition of Derby County’s Lowe, on loan until January, will see Scotland international Shinnie move forward into midfield against Saints.
McInnes said: “We would like to keep Graeme where he and I both think he is both more influential – in the middle of the park.
“I want to keep Graeme in the middle as much as I can and Max can float between that left-back and left-wing back role.
“At times, we have been over reliant on Graeme and Andy Considine in that role. I don’t always want to have to turn to Graeme to play that wide role because then we lose a bit through the middle at times against good opposition.
“Graeme, as a raiding full-back, can still be influential against certain opposition.
“But we do lack that drive, competitiveness and turning the ball over that Graeme brings in midfield.”
on-loan Watford defender Tommie Hoban is set to undergo shoulder surgery and will be out for two to three months.
Mark Reynolds is out until February after knee surgery.
McInnes said: “Max gives us better balance and better options.
“We will be able to have more scope to make those options – whether it is Max, Andy (Considine) or Graeme, we have good options there.”